Summary

Currently employed at Red Brick University. Short biography for the left-hand sidebar

Education

• M.S. in Computational chemistry | 计算化学硕士

  2023
  Nanjing tech University | 南京工业大学
• B.S. in Chemical Engineering and Technology | 化学工程与工艺学士

  2018
  Northwest Normal University | 西北师范大学

Publications

• Catalyst Control over S (IV)-stereogenicity via Carbene-derived Sulfinyl Azolium Intermediates

  2024
  ACS

  Stereoselective synthesis utilizing small-molecule catalysts, particularly N-heterocyclic carbene (NHC), has facilitated swift access to enantioenriched molecules through diverse activation modes and NHC-bound reactive intermediates. While carbonyl derivatives, imines, and “activated” alkenes have been extensively investigated, the exploration of heteroatom-centered analogues of NHC-bound intermediates has long been neglected, despite the significant potential for novel chemical transformations they offer once recognized. Herein, we disclose a carbene-catalyzed new activation mode by generating unique sulfinyl azolium intermediates from carbene nucleophilic addition to in situ-generated mixed sulfinic anhydride intermediates. Combined experimental and computational mechanistic investigations pinpoint the chiral NHC-catalyzed formation of sulfinyl azolium intermediate as the enantio-determining step. The novel “S”-based carbene reactive intermediate imparts high efficiency for the catalytic construction of sulfur-stereogenic compounds, giving rise to sulfinate esters with high yields and enantioselectivities under mild conditions. Notably, distinct from most of the NHC-catalyzed enantioselective transformations focusing on the “C” central chiral products, our study realizes a unique carbene-catalyst control over chiral “S” stereocenters via direct asymmetric S–O bond formation for the first time. Furthermore, these sulfinyl-containing products could serve as versatile synthetic platforms for enantioenriched S-stereogenic functional molecules and exhibit remarkable antibacterial activities against rice plant pathogens, which is valuable for the development of novel agrochemical agents.

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Teaching

• Teaching experience 1

  2014
  University 1, Department

  Role: Undergraduate course

Portfolio

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