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Blog Post number 4
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Blog Post number 3
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Blog Post number 2
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Blog Post number 1
Asymmetric alkylation is a fundamental strategy for the stereoselective construction of chiral molecules, traditionally focusing on control over the carbon stereocenters. Recent advances have extended this approach to heteroatom-centered systems, enabling selective C−heteroatom bond formation to generate heteroatom stereogenicity. While sulfur-based alkylations have attracted considerable attention in recent studies, efcient alkylation strategies for the synthesis of P-stereogenic compounds remain limited despite their pivotal signifcance in catalysis and drug development. Here, we present an organocatalytic enantioselective methylation of prochiral phosphinic acids to access P(V)-stereogenic phosphorus compounds. Employing a cinchonidine-derived phase-transfer catalyst, the formation of a tight ion pair with a prochiral phosphinic acid anion enables highly stereoselective formation of an O−C bond using simple methylating agents under mild conditions. The resulting chiral phosphinates serve as linchpin intermediates that can undergo stereospecifc nucleophilic substitution to afford a broad range of P-stereogenic molecules, including tertiary phosphine oxides, phosphinamides, and phosphinates. These chiral phosphorus compounds display promising biological activities, underscoring their potential in the development of agrochemical agents.
portfolio
| 2025年4月 | 参加第一届全国有机化学化工产学研会议 |
参加第一届全国有机化学化工产学研会议，并做邀请报告《AI for science:工业催化剂研发的新范式》.
| 2023年5月 | 我研究生毕业了 |
非常感谢大学的好哥们陈涛来给我拍毕业照，选取我认为最帅的一张. 
publications
1.Yuanyuan Qu, Junyuan Hu, Fengzhen Guo, Dong Ji, Yuguang Li, Zhenjiang Li, Yunsheng Xu, Jin Huang*, Lili Zhao*, Kai Guo*,Understanding Alkali Cation-Assisted Ring-Opening Polymerization of Macrocyclic Carbonate: Kinetics and Thermodynamics,Macromolecules 2023, 56, 6790−6797.
文献解读：高分子科学前沿
2.Benpeng Li#, Junyuan Hu#, Minghong Liao, Qin Xiong, Yaqi Zhang, Yonggui Robin Chi, Xinglong Zhang*, Xingxing Wu*,Catalyst Control over S (IV)-stereogenicity via Carbene-derived Sulfinyl Azolium Intermediates,J. Am. Chem. Soc. 2024, 146, 25350−25360.
3.Fengrui Che#, Junyuan Hu#, Minghong Liao#, Zhongfu Luo, Hongyan Long, Benpeng Li, Yonggui Robin Chi, Xingxing Wu*,Synthesis of P (V)-Stereogenic Phosphorus Compounds via Organocatalytic Asymmetric Condensation,J. Am. Chem. Soc. 2024, 146, 33763−33773.
4.Sheng Zhang*, Lei Hong, Jiayi Feng, Mohan Wang,Junyuan Hu, Ying Zhang, Man-Bo Li*,Bimetallic [Co/K] hydrogen evolution catalyst for electrochemical terminal C-H functionalization,Nat. Commun.2025,16,8435.
文献解读:安徽大学
5.Benpeng Li#, Junyuan Hu#,Zhengtao Xu, Minghong Liao, Yonggui Robin Chi, Xingxing Wu*,Control Over S(VI) Stereogenicity for the Asymmetric Synthesis of Sulfonimidoyl Derivatives by Isothiourea-Catalyzed Covalent Activation of Sulfur(VI) Atoms,Angew. Chem. Int. Ed.2025, 64, e202510595.
文献解读:化学深耕堂
6.Fengrui Che, Junyuan Hu*,Benpeng Li, Yanyan Wang, Xingxing Wu*, Yonggui Robin Chi*,Asymmetric Organocatalytic Methylation of Prochiral Phosphinic Acids: Construction of P(V)-Stereogenic Centers,ACS Catal. 2025, 15, 20184−20193.
文献解读:绿色农药全国重点实验室、化学深耕堂
7.Xianghua Zhao, Xinyu Chen, Linxian Fan, Yulong Jiang, Yirui Chen, Dingguo Song, Fei Ling*,Junyuan Hu*, Weihui Zhong*,Bulky alkali metal cations enabled highly efficient iridium-catalyzed asymmetric hydrogenation for C–N axial chirality via dynamic kinetic resolution,Chem. Sci. 2025, 10.1039/D5SC08462H.
talks
Talk 1 on Relevant Topic in Your Field
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Conference Proceeding talk 3 on Relevant Topic in Your Field
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